Key result
In spontaneously hypertensive rats, the anticontractile effect of perivascular adipose tissue and leptin on angiotensin II-induced contractions is abolished compared to normotensive rats.
Population
Aorta from Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)
Comparison
Presence of perivascular adipose tissue and… vs Absence of PVAT and WKY rats as normotensive…
Design
Preclinical
Authors
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Should not change hypertension management; hypothesis-generating for leptin-mediated perivascular effects in animal models.
Absolute Event Rate: 502% vs 289%
p-value: p=<0.05
In spontaneously hypertensive rats, the anticontractile effect of perivascular adipose tissue is reduced due to decreased leptin production and impaired leptin-induced endothelial nitric oxide release.
Gálvez-Prieto et al. (2012) studied Hypertension (n=32). Hypertension (SHR strain) vs. Normotension (WKY strain) was evaluated on Maximal contraction (Emax) to Angiotensin II in the presence of perivascular adipose tissue (p=<0.05). In spontaneously hypertensive rats, the anticontractile effect of perivascular adipose tissue and leptin on angiotensin II-induced contractions is abolished compared to normotensive rats.
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