Key result
Perivascular adipose tissue modulates vascular smooth muscle contractions, and its anticontractile effect is attenuated in hypertension, potentially due to increased proinflammatory factors.
Population
General discussion of perivascular adipose tissue (PVAT) and prehypertensive rats
Design
Review
Authors
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Hypothesis-generating for PVAT-targeted hypertension therapies; leaves open whether modulating inflammation restores anticontractile effects clinically.
Perivascular adipose tissue modulates vascular reactivity, and its anticontractile properties are attenuated in hypertension, possibly driven by inflammation and macrophage infiltration.
Mabayoje A. Oriowo (2014) conducted a review in Hypertension. Perivascular adipose tissue modulates vascular smooth muscle contractions, and its anticontractile effect is attenuated in hypertension, potentially due to increased proinflammatory factors.
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