Angiotensin II, atherosclerosis, and aortic aneurysms
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Why the study?
Does Angiotensin II infusion promote atherosclerosis and aortic aneurysms in apoE-/- mice?
Population
apoE-/- mice, which have increased total cholesterol and VLDL/LDL levels and develop spontaneous…
Comparison
Angiotensin II infusion vs Strain matched apoE+/+ mice
Design
Editorial
Authors
Discussion
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Member takes
Implication
This commentary highlights that Angiotensin II directly promotes atherosclerosis and abdominal aortic aneurysms in hyperlipidemic mice, providing mechanistic rationale for the clinical benefits of ACE inhibitors in vascular disease.
Structured PICO
Does Angiotensin II infusion promote atherosclerosis and aortic aneurysms in apoE-/- mice?
P
Population
apoE-/- mice, which have increased total cholesterol and VLDL/LDL levels and develop spontaneous atherosclerosis even when fed a low-fat, low-cholesterol diet
I
Intervention
Angiotensin II infusion
C
Comparator
Strain matched apoE+/+ mice
O
Outcome
Vascular pathology, including an increase in the extent of atherosclerosis, a change in the nature of lesions and surrounding adventitial tissue, and formation of large abdominal aortic aneurysmssurrogate
This commentary highlights that Angiotensin II directly promotes atherosclerosis and abdominal aortic aneurysms in hyperlipidemic mice, providing mechanistic rationale for the clinical benefits of ACE inhibitors in vascular disease.
Cite This Study
Berk et al. (2000) studied this question.
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