Why the study?
Does perindopril prevent atherosclerosis-induced structural and functional arterial changes in minipigs on an atherogenic diet?
Population
21 adult Pitman-Moore minipigs (7 months of age)
Comparison
Perindopril 4 mg PO daily concomitantly with an… vs Atherogenic diet alone and control diet
Design
Preclinical
Follow-up
4 months
Authors
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Does not support clinical use; leaves open translation of perindopril's arterial effects from minipig atherosclerosis models.
Does perindopril prevent atherosclerosis-induced structural and functional arterial changes in minipigs on an atherogenic diet?
In a minipig model, ACE inhibition with perindopril prevented atherosclerosis-induced arterial stiffness and reduced the development of atherosclerotic lesions.
Charpiot et al. (1993) studied this question.
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