Why the study?
Does the withdrawal of spironolactone increase atrial natriuretic peptide levels to mediate the mineralocorticoid escape phenomenon in patients with primary aldosteronism?
Does the withdrawal of spironolactone increase atrial natriuretic peptide levels to mediate the mineralocorticoid escape phenomenon in patients with primary aldosteronism?
The mineralocorticoid escape phenomenon following spironolactone withdrawal in primary aldosteronism is associated with a significant increase in plasma ANP levels, which may mediate the escape from sodium retention.
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May implicate ANP in mineralocorticoid escape after spironolactone withdrawal; hypothesis-generating from single case and should not change practice.
Nakamura et al. (1987) studied this question.