Why the study?
Does spironolactone improve urinary Na+ excretion and alter plasma hormone responses in Na(+)-retaining CHF patients?
Does spironolactone improve urinary Na+ excretion and alter plasma hormone responses in Na(+)-retaining CHF patients?
Spironolactone reverses positive sodium balance in CHF patients, highlighting the renin-angiotensin-aldosterone system as a key mediator of sodium retention.
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Hypothesis-generating in CHF; leaves open whether spironolactone effects on sodium balance improve outcomes in trials.
Hensen et al. (2008) studied this question.
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