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December 19, 2013Journal of Pharmaceutical AnalysisOpen Access

Simultaneous determination of amlodipine, valsartan and hydrochlorothiazide by LC–ESI-MS/MS and its application to pharmacokinetics in rats

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Authors

SGShankar Ganesh GadepalliIndian Institute of Chemical Technology PDPragney DemeTulane University MKMadhusudana KunchaIndian Institute of Chemical Technology

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Implication

New LC-MS/MS method enables polypill component quantification; leaves open routine clinical or pharmacokinetic application pending validation.

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Gadepalli et al. (2013) studied this question.

synapsesocial.com/papers/6a739dc55946a55bc0fb6fdd https://doi.org/10.1016/j.jpha.2013.12.003

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Synapse has enriched one closely related paper. Consider it for comparative context:

1Development and validation of a highly sensitive and robust LC‐ESI‐MS/MS method for simultaneous quantitation of simvastatin acid, amlodipine and valsartan in human plasma: application to a clinical pharmacokinetic study2009 · 54 citations