November 1, 2014Development and Psychopathology

Atypical patterns of respiratory sinus arrhythmia index an endophenotype for depression

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Why the study?

Do atypical patterns of respiratory sinus arrhythmia serve as an endophenotype for depression?

Structured PICO

Do atypical patterns of respiratory sinus arrhythmia serve as an endophenotype for depression?

Population

Mothers with and without depression histories and their offspring (at high and low risk for depression), and adolescent sibling pairs concordant and discordant for major depression.

Intervention

Sad mood induction with monitoring of respiratory sinus arrhythmia (RSA) during rest and in response to mood induction.

Comparator

Normative RSA patterns; low-risk peers; discordant sibling pairs.

Outcome

Atypical RSA patterns as an endophenotype for depression (predicting depressive episodes, longitudinal trajectories, and concordance among relatives).surrogate

Atypical patterns of respiratory sinus arrhythmia may serve as a physiological endophenotype for depression risk.

Discussion

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Implication

Atypical RSA may mark depression vulnerability in youth; hypothesis-generating for endophenotype status, requiring prospective validation before any clinical use.

Cite This Study

Yaroslavsky et al. (2014) studied this question.

synapsesocial.com/papers/6a73a2ff61762fa209a73258 https://doi.org/10.1017/s0954579414001060

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Implication

Atypical RSA may mark depression vulnerability in youth; hypothesis-generating for endophenotype status, requiring prospective validation before any clinical use.

Atypical patterns of respiratory sinus arrhythmia index an endophenotype for depression

Structured PICO

Discussion

Implication

Cite This Study

Atypical patterns of respiratory sinus arrhythmia index an endophenotype for depression

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider