March 1, 1993Molecular and Cellular Biology

Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism.

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Population

mRNAs containing the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region elementn

Design

Preclinical

Authors

TATerri AharonColumbia University Irving Medical Center RSR J SchneiderNew York University

Discussion

Member takes

Implication

Hypothesis-generating for AU-rich mRNA decay; leaves open translation to human cardiovascular models or therapies.

Structured PICO

Population

mRNAs containing the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region element (AUUUA)n

Intervention

Introduction of stable secondary structure in the 5' noncoding region and insertion of poliovirus internal ribosome entry site

Outcome

mRNA stability and targeted destabilization

The study demonstrates that selective mRNA degradation mediated by the (AUUUA)n element is coupled to ribosome binding or ongoing translation rather than 5'-to-3' exonuclease activity.

Cite This Study

Aharon et al. (1993) studied this question.

synapsesocial.com/papers/6a73a3051aa2fc9e78fb6d41 https://doi.org/10.1128/mcb.13.3.1971

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Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider