September 1, 2002Journal of Hypertension
Blood pressure variability, target organ damage and cardiovascular events
Why the study?
Does increased blood pressure variability induced by sino-aortic denervation cause cardiovascular structural changes in rats?
Population
Rats (animal model)
Comparison
Sino-aortic denervation to increase blood… vs Sham procedure
Design
Editorial
Follow-up
2, 10, and 16 weeks
Authors
Discussion
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Implication
Increased blood pressure variability, independent of mean blood pressure, is associated with early aortic hypertrophy followed by left ventricular hypertrophy in a rat model.
Structured PICO
Does increased blood pressure variability induced by sino-aortic denervation cause cardiovascular structural changes in rats?
P
Population
Rats (animal model)
I
Intervention
Sino-aortic denervation (SAD) to increase blood pressure variability
C
Comparator
Sham procedure
O
Outcome
Development of hypertrophy in the aorta and in the left ventriclesurrogate
Increased blood pressure variability, independent of mean blood pressure, is associated with early aortic hypertrophy followed by left ventricular hypertrophy in a rat model.
Limitations
- Lack of new insights into the mechanisms underlying the reported cardiovascular alterations of SAD rats
Cite This Study
Parati et al. (2002) studied this question.