Combination chemotherapy with capecitabine and oxaliplatin may be associated with the development of acute arterial thrombosis, such as aortic thrombosis, requiring clinical awareness.
Clinicians should consider arterial thrombosis risk with capecitabine-oxaliplatin; this case report is hypothesis-generating and should not change practice.
This case report describes a 68-year-old male who presented to the emergency department (ED) with nausea, vomiting, abdominal pain, diarrhea, and fatigue after starting adjuvant combination chemotherapy with capecitabine and oxaliplatin two weeks prior. Further evaluation of this patient in the ED revealed an incidentally discovered aortic thrombosis, of which this patient did not exhibit any specific symptoms. This case, among a few others, has described the development of arterial thrombosis in patients with cancer undergoing combination chemotherapy with capecitabine and oxaliplatin.
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Burton et al. (2023) studied this question.
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