Key result
Cisplatin-based chemotherapy linked to severe arterial and intracardiac thrombosis in reduced LVEF.
Why the study?
Spontaneous arterial thrombosis after cisplatin-based chemotherapy in patients without aneurysmal or grossly atheromatous aorta is rare and not well characterized.
Case Report (n=1)
Highlights a rare case of acute, severe arterial and intra-cardiac thrombosis occurring immediately after cisplatin-based chemotherapy, suggesting a potential hypercoagulable effect.
Answers are grounded in this paper and cite their sources.
May warrant vigilance for thrombosis with cisplatin in low-LVEF malignancy; hypothesis-generating case leaves causal link and generalizability open.
We present a rare case of spontaneous arterial thrombosis in a 42-year-old male with an acute history of bilateral lower limb pain and weakness. The previous day he had received the first cycle of cisplatin-based chemotherapy for oesophageal adenocarcinoma (T2/3N0/M0). Computed tomography (CT) and angiography showed extensive abdominal aortic thrombus in a native non-aneurysmal or grossly atheromatous aorta with separate thrombus in the left ventricle. We suggest that poor left ventricular function, a hypercoaguable state secondary to malignancy and cisplatin based chemotherapy may have induced severe arterial and intra-cardiac thrombosis.
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Morlese et al. (2007) conducted a case report in Oesophageal adenocarcinoma (n=1). Cisplatin-based chemotherapy was evaluated on Spontaneous arterial and intra-cardiac thrombosis. Cisplatin-based chemotherapy, in the setting of malignancy and poor left ventricular function, was associated with severe arterial and intra-cardiac thrombosis in a 42-year-old male.
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