Key result
Cisplatin-based chemotherapy in patients with cancer was associated with acute thrombosis of the abdominal aorta in 4 reported cases.
Case Report (n=4)
Acute thrombosis of the aorta is a rare but potentially fatal complication in cancer patients receiving cisplatin-based chemotherapy, requiring high clinical suspicion for prompt diagnosis and treatment.
Alerts clinicians to possible aortic thrombosis in cisplatin-treated cancer patients; case reports leave causality and incidence open.
The increased risk of thrombosis in patients with active cancer has multiple causes. Acute thrombosis of the aorta is an exceedingly rare but potentially devastating complication in patients with cancer receiving cisplatin-based chemotherapy. Prompt diagnosis and definitive treatment are imperative to decrease morbidity and mortality. Early diagnosis is difficult because initial presentation is often nonspecific, requiring a high degree of clinical suspicion. We report 4 cases of acute thrombosis of the abdominal aorta in patients with cancer receiving cisplatin-based chemotherapy. We review the clinical aspects, recommended investigation, and treatment of this potentially fatal complication.
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Fernandes et al. (2011) conducted a case report in Cancer (n=4). Cisplatin-based chemotherapy was evaluated on Acute thrombosis of the abdominal aorta. Cisplatin-based chemotherapy in patients with cancer was associated with acute thrombosis of the abdominal aorta in 4 reported cases.
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