Aortic fibrosis and vascular stiffening in hypertension are primarily driven by the recruitment and transformation of Sca-1(+) progenitor cells and bone marrow-derived fibrocytes, challenging the traditional view that resident fibroblasts are the main source.
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May identify alternative collagen sources in hypertensive vessels; hypothesis-generating without clinical implications yet.
Wu et al. (2015) studied this question.
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