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July 1, 2014Cell ReportsOpen Access

Labeling of endothelial cells in the adult heart yields progeny that have cardiac stem cell characteristics (expressing Gata4 and Sca1) and generate clusters of cardiomyocytes in specific regions of the heart.

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Population

Adult heart model (using Cre/Lox-based cell lineage tracing strategies)

Design

Preclinical

Authors

BFBryan A. FioretJHJeremy D. HeimfeldDPDavid T. Paik

Discussion

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Overview

Endothelial contribution to adult cardiomyocyte generation in mice should not alter clinical practice; leaves open its relevance to human heart regeneration.

Structured PICO

P
Population
Adult heart model (using Cre/Lox-based cell lineage tracing strategies)
I
Intervention
Labeling of endothelial cells using Cre/Lox-based cell lineage tracing strategies
O
Outcome
Generation of adult ventricular myocytes and identification of cardiac stem cell characteristicssurrogate

Endothelial cells are an intrinsic component of the cardiac renewal process, contributing to the generation of adult ventricular myocytes during homeostasis.

Cite This Study

Fioret et al. (2014) studied this question.

synapsesocial.com/papers/6a8566b668d2ad262cd59568https://doi.org/10.1016/j.celrep.2014.06.004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells2014 · 49 citations
  2. 2Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult Heart2018 · 81 citations
  3. 3Sca1-Derived Cells Are a Source of Myocardial Renewal in the Murine Adult Heart2013 · 153 citations
  4. 4Genetic Lineage Tracing of Nonmyocyte Population by Dual Recombinases2018 · 207 citations
  5. 5Genetic Lineage Tracing of Sca-1 <sup>+</sup> Cells Reveals Endothelial but Not Myogenic Contribution to the Murine Heart2018 · 99 citations