Population
Inducible adult endocardial Cre line (Npr3-CreER) mice
Comparison
4 cardiac injury models: myocardial infarction… vs Cardiac homeostasis (uninjured state)
Design
Preclinical
Key result
Unlike fetal or neonatal endocardium, adult endocardium generates minimal, if any, coronary arteries or vascular endothelial cells during cardiac homeostasis or after cardiac injuries.
Authors
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Questions endocardial targeting for adult neovascularization; leaves open primary cellular sources of coronary endothelium post-injury.
Unlike fetal or neonatal endocardium, adult endocardial cells do not significantly contribute to neovascularization after cardiac injury.
Tang et al. (2018) studied Cardiac injury. Cardiac injury models (myocardial infarction, ischemia-reperfusion, cryoinjury, transverse aortic constriction) vs. Homeostasis (uninjured) was evaluated on Contribution of adult endocardium to coronary endothelial cells. Unlike fetal or neonatal endocardium, adult endocardium generates minimal, if any, coronary arteries or vascular endothelial cells during cardiac homeostasis or after cardiac injuries.
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