Key result
Preexisting endothelial cells, rather than fibroblasts undergoing mesenchymal-to-endothelial transition, almost exclusively mediate cardiac neovascularization after myocardial injury.
Population
Adult mouse models of myocardial ischemia-reperfusion injury using multiple genetic lineage-tracing lines.
Comparison
Genetic lineage tracing followed by myocardial… vs Uninjured hearts and different cell lineages.
Design
Preclinical
Follow-up
1 to 2 weeks post-injury
Authors
Loading...
Challenges MEndoT as major source of post-MI coronary endothelium; leaves open whether targeting preexisting EC proliferation aids repair.
Cardiac neovascularization after injury is driven almost exclusively by preexisting endothelial cells, refuting the hypothesis that fibroblasts undergo mesenchymal-to-endothelial transition.
He et al. (2017) studied Myocardial ischemia-reperfusion injury. Myocardial ischemia-reperfusion injury vs. Sham injury was evaluated on Contribution of fibroblasts to new coronary endothelial cells (mesenchymal-to-endothelial transition). Preexisting endothelial cells, rather than fibroblasts undergoing mesenchymal-to-endothelial transition, almost exclusively mediate cardiac neovascularization after myocardial injury.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: