Why the study?
Does captopril reduce aldosterone secretion and blood pressure rise during ACTH infusion in normal men?
Does captopril reduce aldosterone secretion and blood pressure rise during ACTH infusion in normal men?
Angiotensin II partially mediates the effect of ACTH on aldosterone secretion and blood pressure, as demonstrated by the blunting of these responses with captopril.
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Suggests angiotensin II mediation of ACTH effects in normals; hypothesis-generating and leaves open clinical relevance.
Oelkers et al. (1982) studied this question.
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