Why the study?
Does des-Asp1-,Ileu8-angiotensin II suppress captopril-induced increases in plasma renin activity in normal and hypertensive men?
Population
10 men (5 normal men and 5 hypertensive patients, including 1 with renovascular hypertension)
Comparison
Captopril 100 mg oral immediately before a… vs Captopril 100 mg oral alone; AIIIA 200 ng/kg.min…
Design
Other
Follow-up
2 hours
Authors
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Supports angiotensin II feedback loss as driver of captopril-induced PRA rise; hypothesis-generating and should not yet change practice.
Does des-Asp1-,Ileu8-angiotensin II suppress captopril-induced increases in plasma renin activity in normal and hypertensive men?
The suppression of captopril-induced plasma renin activity increase by an angiotensin II derivative suggests the increase is primarily due to the disappearance of endogenous angiotensin II.
Kono et al. (1981) studied this question.
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