Why the study?
What is the biological activity of des-asp1-des-arg2-angiotensin II on blood pressure, renin, and aldosterone in humans?
Population
5 normal men and 2 patients with Bartter's syndrome (n=7)
Design
Other
Follow-up
60 to 120 minutes
Authors
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Does not support clinical use; leaves open whether 3-8AII has therapeutic potential in renin-driven disorders.
What is the biological activity of des-asp1-des-arg2-angiotensin II on blood pressure, renin, and aldosterone in humans?
The hexapeptide 3-8AII demonstrates significant renin-suppressing action with minimal pressor and weak aldosterone-stimulating effects in humans.
Kono et al. (1982) studied this question.
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