What question did this study set out to answer?

This research investigates the feasibility of a collaborative trial comparing warfarin and aspirin for preventing ischemic stroke recurrence.

The Feasibility of a Collaborative Double-Blind Study Using an Anticoagulant

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Highlights feasibility of multicenter stroke trials; leaves open optimal antithrombotic strategy for secondary prevention.

This research investigates the feasibility of a collaborative trial comparing warfarin and aspirin for preventing ischemic stroke recurrence.
Conducted as a randomized, double-blind multicenter trial involving 1,920 participants.
The primary outcome focuses on recurrence of ischemic stroke or death over 2 years.
Utilized a combined database with standardization in laboratory processes and double blinding for INR values.
Cumulative patient recruitment of over 1,400 across 50 sites by June 1, 1996.
The study presents evidence of the feasibility of collaborative trials in stroke research.
Data from related studies will provide insights into risk factors for stroke and treatment efficacy.

A 1997 study studied this question.

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