Why the study?
Does warfarin reduce the frequency of stroke and death in patients with prior stroke compared to aspirin?
Population
Planned > 1,900 patients for the prevention of recurrent stroke
Comparison
Warfarin (dosed to maintain INR 1.4-2.8) vs Aspirin 325 mg q.i.d.
Design
RCT, Randomized, Double-blind
Authors
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Double-blind sham-INR design enables unbiased warfarin-aspirin comparison in secondary stroke prevention; delivers definitive RCT evidence on anticoagulation versus antiplatelet therapy.
Does warfarin reduce the frequency of stroke and death in patients with prior stroke compared to aspirin?
The WARSS trial is designed to compare warfarin versus aspirin for the prevention of recurrent stroke using a novel double-blind methodology with sham INR reporting.
J.P. Mohr (2007) studied this question.
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