Population
Embryos (preclinical model) with Tie2-Cre transgene
Comparison
Selective inactivation of Gata4 within… vs Wild-type embryos (implied)
Design
Preclinical
Authors
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Supports Gata4-Erbb3-Erk axis in valve morphogenesis; hypothesis-generating for congenital defects pending human studies.
Gata4 is essential for atrioventricular valve development by regulating the Erbb3-Erk pathway for EMT and promoting cushion mesenchyme growth.
Rivera‐Feliciano et al. (2006) studied this question.
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