Why the study?
Does targeted deletion of Gata5 lead to bicuspid aortic valve formation in mice?
Does targeted deletion of Gata5 lead to bicuspid aortic valve formation in mice?
Gata5 deletion in mice causes bicuspid aortic valve formation, identifying GATA5 as a potential candidate gene for human congenital heart disease.
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Positions GATA5 as candidate gene for human BAV; hypothesis-generating and requires validation before clinical consideration.
Laforest et al. (2011) studied this question.
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