Why the study?
Are cardiovascular risk factors associated with insulin resistance clustered in probands with early-onset CHD compared to their unaffected siblings?
Are cardiovascular risk factors associated with insulin resistance clustered in probands with early-onset CHD compared to their unaffected siblings?
Cardiovascular risk factors associated with insulin resistance syndrome cluster in individuals with early-onset CHD compared to their unaffected siblings, suggesting an indirect contribution to disease pathogenesis.
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Metabolic clustering may flag higher-risk families for screening; leaves open causal role of insulin resistance in early CHD.
Kareinen et al. (2001) studied this question.
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