Why the study?
Does single-dose dexlansoprazole MR prolong the QT interval in healthy participants?
Population
40 healthy participants
Comparison
Single oral doses of dexlansoprazole MR 90 mg… vs Single oral dose of moxifloxacin 400 mg and…
Design
RCT, Randomized, 4-period crossover, Placebo-controlled
Follow-up
24 hours post-dose
Authors
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Supports safe dexlansoprazole MR use without QT monitoring; confirms no clinically relevant QTc prolongation in healthy participants.
Does single-dose dexlansoprazole MR prolong the QT interval in healthy participants?
Dexlansoprazole MR at doses up to 300 mg does not cause clinically significant QT interval prolongation in healthy participants.
Vakily et al. (2009) studied this question.
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