January 30, 2003BloodOpen Access

Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI–mediated Rap1 activation in platelets

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Population

Human platelets, murine platelets (including knockout mice deficient in P2Y1 or Galphai2), and RBL-2H3 cells

Design

Preclinical

Authors

MLMark K. LarsonAugustana University HCHong ChenTongji Hospital MKMark L. KahnUniversity of Pennsylvania

Discussion

Member takes

Implication

Does not alter antiplatelet regimens; leaves open PI3K/epinephrine targeting of P2Y12-independent Rap1 in future human studies.

Structured PICO

Population

Human platelets, murine platelets (including knockout mice deficient in P2Y1 or Galphai2), and RBL-2H3 cells

Intervention

GPVI activation via convulxin, ADP receptor antagonists, and epinephrine

Outcome

Mechanisms of GPVI-mediated Rap1 activationsurrogate

This study defines the mechanisms of GPVI-mediated platelet activation, highlighting Rap1 as a key signaling protein activated via both P2Y12-dependent and -independent pathways.

Cite This Study

Larson et al. (2003) studied this question.

synapsesocial.com/papers/6a73b1db38bf1d836e1af9ae https://doi.org/10.1182/blood-2002-05-1533

View Full Paper

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Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI–mediated Rap1 activation in platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of P2Y12-dependent and -independent mechanisms of glycoprotein VI–mediated Rap1 activation in platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider