Why the study?
Is visceral adipose tissue associated with circulating high affinity growth hormone-binding protein (GHBP) levels in patients with GH deficiency and healthy subjects?
Population
12 patients with GH deficiency (GHD) and 12 age- and sex-matched healthy subjects
Comparison
GH replacement therapy (in GHD patients) vs Healthy subjects and pre-treatment status
Design
Cohort
Authors
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Visceral fat may influence GHBP in GHD; observational data leave open whether targeting adiposity alters replacement response.
Is visceral adipose tissue associated with circulating high affinity growth hormone-binding protein (GHBP) levels in patients with GH deficiency and healthy subjects?
Visceral fat mass is associated with circulating GHBP levels and may partially determine the plasma GHBP response to GH replacement therapy in GHD patients.
Roelen et al. (1997) studied this question.
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