Why the study?
Does diet-induced weight loss or short-term hypocaloric feeding affect serum GHBP levels in obese subjects?
Population
18 obese subjects and 18 age- and sex-matched normal subjects.
Comparison
Diet-induced massive weight loss and short-term… vs Age- and sex-matched normal subjects, and…
Design
Cohort
Authors
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GHBP elevation in obesity normalizes after massive weight loss; hypothesis-generating for fat mass regulation, needs prospective confirmation before clinical relevance.
Does diet-induced weight loss or short-term hypocaloric feeding affect serum GHBP levels in obese subjects?
GHBP levels are elevated in obesity and normalize with massive weight loss, suggesting regulation by fat mass rather than acute nutritional changes or insulin.
Rasmussen et al. (1996) studied this question.
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