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July 1, 1984Biochemical JournalOpen Access

Expression of myosin isoenzymes in cardiac-muscle cells in culture

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Population

Rat and chicken embryonic cardiac myocytes in culture

Comparison

L-thyroxine (T4) at physiological concentration vs Untreated cultured myocytes and in vivo…

Design

Preclinical

Follow-up

7 days in culture

Authors

ANAsish C. NagUniversity of WashingtonMCMing ChengHenan Provincial People's Hospital

Discussion

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Implication

Caution against clinical extrapolation; leaves open in vivo and human confirmation of T4 effects on cardiac myosin.

Structured PICO

P
Population
Rat and chicken embryonic cardiac myocytes in culture (18-day-embryonic-rat myocytes, 7-day-old intact embryonic-chicken ventricles and isolated myocytes)
I
Intervention
L-thyroxine (T4) at physiological concentration
C
Comparator
Untreated cultured myocytes and in vivo counterparts (young and adult ventricles)
O
Outcome
Myosin isoenzyme profiles and Ca2+-activated ATPase activitysurrogate

Physiological concentrations of L-thyroxine can modulate the expression of myosin isoenzymes from fetal to adult types in cultured embryonic rat cardiac myocytes.

Cite This Study

Nag et al. (1984) studied this question.

synapsesocial.com/papers/6a73b97cd0d1650e4d69ef8ahttps://doi.org/10.1042/bj2210021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Species correlations between cardiac isomyosins. A comparison of electrophoretic and immunological properties.1982 · 177 citations
  2. 2Effect of the thyroid state on the enzymatic characteristics of cardiac myosin. A difference in behavior of rat and rabbit cardiac myosin.1975 · 128 citations
  3. 3Electrophoretic analysis of multiple forms of myosin in fast-twitch and slow-twitch muscles of the chick1976 · 280 citations
  4. 4Actin-activated adenosine triphosphatase activity of native and N-ethylmaleimide-modified cardiac myosin from normal and thyrotoxic rabbits.1977 · 36 citations
  5. 5Calcium-activated muscle from hypertrophied rabbit hearts. Mechanical and correlated biochemical changes.1979 · 77 citations