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February 1, 1979Circulation ResearchOpen Access

Calcium-activated muscle from hypertrophied rabbit hearts. Mechanical and correlated biochemical changes.

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Population

Chemically skinned ventricular preparations from rabbit hearts with hypertrophy produced by sustained…

Comparison

Direct activation with calcium solutions after… vs Multicellular bundles from control right…

Design

Preclinical

Authors

DMDavid W. MaughanUniversity of VermontELElizabeth LowAustralian Research CouncilRLRaye Z. LittenUniversité Bourgogne Franche-Comté

Discussion

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Implication

Implicates reduced myosin cross-bridge cycling in hypertrophic dysfunction; leaves open translation to human heart failure therapies.

Structured PICO

P
Population
Chemically skinned ventricular preparations from rabbit hearts with hypertrophy produced by sustained pulmonary constriction, and control rabbit hearts.
I
Intervention
Direct activation with calcium solutions after treatment with Brij-58 (a non-ionic detergent).
C
Comparator
Multicellular bundles from control right ventricles of rabbit hearts.
O
Outcome
Isotonic shortening rate, unloaded velocity of shortening, and myosin ATPase activities.surrogate

Hypertrophied rabbit ventricular muscle exhibits reduced shortening velocity and depressed myosin ATPase activity, indicating decreased myosin crossbridge cycling rates.

Cite This Study

Maughan et al. (1979) studied this question.

synapsesocial.com/papers/6a899ee70f137e402b3355f2https://doi.org/10.1161/01.res.44.2.279
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanical Properties of Rat Cardiac Muscle during Experimental Hypertrophy1971 · 288 citations
  2. 2Isometric force development, isotonic shortening, and elasticity measurements from Ca2+-activated ventricular muscle of the guinea pig.1978 · 36 citations
  3. 3Mechanism for the Abnormal Energetics of Pressure-Induced Hypertrophy of Cat Myocardium1973 · 120 citations
  4. 4Rat myocardial mechanics during pressure-induced hypertrophy development and reversal1975 · 67 citations
  5. 5Studies of Cardiac Muscle with a High Permeability to Calcium Produced by Treatment with Ethylenediaminetetraacetic Acid1971 · 139 citations