What question did this study set out to answer?

To assess how cardiac hypertrophy alters myocardial contractile performance by simultaneously measuring isometric tension, ATPase activity, and sarcomere length.

November 1, 1972Circulation Research

Simultaneously Measured Isometric Tension and ATP Hydrolysis in Glycerinated Fibers from Normal and Hypertrophied Rabbit Heart

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Authors

PHPhilip D. HenryEast Tennessee State University GAG G AhumadaWashington University in St. Louis WFWilliam F. FriedmanAmerican Heart Association

Discussion

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Implication

Preserved efficiency in hypertrophied rabbit fibers warrants no clinical change; leaves open whether myofibrillar adaptations translate to human HF.

Key Points

To assess how cardiac hypertrophy alters myocardial contractile performance by simultaneously measuring isometric tension, ATPase activity, and sarcomere length.
Simultaneously measured radiochromatographic ATPase activity, isometric tension, and sarcomere length in glycerinated fibers from 14 hypertrophied and 18 normal rabbit hearts.
Excluded enzymatic contributions from mitochondria, sarcolemma, and sarcoplasmic reticulum, and evaluated isolated myofibrils, actomyosin, and homogenates.
Total ATPase activity associated with contraction at a given developed tension was significantly decreased in hypertrophied fibers (P < 0.001), as well as in isolated myofibrils, actomyosin, and homogenates.
Active length-tension and tension-pCa relationships were preserved in hypertrophied fibers, and the rate of ATPase increase per unit of developed tension was identical between groups.

Cite This Study

Henry et al. (1972) studied this question.

synapsesocial.com/papers/6a74cca501b447f0dadbeb11 https://doi.org/10.1161/01.res.31.5.740

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Implication

Preserved efficiency in hypertrophied rabbit fibers warrants no clinical change; leaves open whether myofibrillar adaptations translate to human HF.

Simultaneously Measured Isometric Tension and ATP Hydrolysis in Glycerinated Fibers from Normal and Hypertrophied Rabbit Heart

Discussion

Member takes

Implication

Key Points

Cite This Study

Simultaneously Measured Isometric Tension and ATP Hydrolysis in Glycerinated Fibers from Normal and Hypertrophied Rabbit Heart

Discussion

Member takes

Implication

Key Points

Cite This Study

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