Population
Rabbits with long-term volume-overload hypertrophy
Comparison
Creation of an aortocaval shunt to induce… vs Sham-operated controls (SOC)
Design
Preclinical
Follow-up
approximately 12 weeks
Authors
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Preserved myocardial efficiency in rabbit volume overload challenges metabolic remodeling hypotheses; leaves open translation to human heart failure.
In a rabbit model of long-term volume overload, mechanical efficiency and key biochemical properties of the myocardium remain largely preserved despite hypertrophy and prolongation of contractile duration.
Gibbs et al. (1992) studied this question.
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