Population
Young rabbits
Comparison
Long-term pressure-overload hypertrophy induced… vs Sham-operated controls (SOC)
Design
Preclinical
Follow-up
10-16 weeks
Authors
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May signal Ca2+ dysregulation in compensated hypertrophy; leaves open translation to human HF energetics.
Long-term compensated hypertrophy in rabbit hearts shows few mechanical and energetic differences from controls, with detectable changes primarily reflecting disturbances in cellular Ca2+ regulation.
Gibbs et al. (1990) studied this question.
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