Population
Isolated small right ventricular rabbit trabeculae
Comparison
Prolonged isometric contractions at high, but… vs Muscles subjected to a low preload, or in the…
Design
Preclinical
Follow-up
48 hours
Authors
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Does not alter clinical practice; leaves open translation of load-driven hypertrophy from isolated rabbit myocardium to human disease.
Mechanical overload alone, in the absence of systemic factors, is sufficient to induce rapid hypertrophy and functional/proteomic changes in isolated adult rabbit myocardium.
Bupha‐Intr et al. (2007) studied this question.
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