Why the study?
Does alprenolol improve clinical symptoms in patients with angina pectoris compared to pentanitrol and placebo?
Does alprenolol improve clinical symptoms in patients with angina pectoris compared to pentanitrol and placebo?
Alprenolol 100 mg four times daily provides significant clinical improvement in patients with angina pectoris compared to pentanitrol and placebo.
Alprenolol improves angina symptoms; supports beta-blocker preference and strengthens RCT evidence versus nitrates.
Twenty-one patients with angina pectoris took part in a double-blind cross-over comparison of alprenolol (an adrenergic beta-blocker), pentanitrol (pentaerythritol tetranitrate), and placebo. Two-thirds of the patients were clinically improved on alprenolol 100 mg. four times daily, which was found to be significantly better than pentanitrol 30 mg. four times daily and placebo. There was also an indication of reduced severity of anginal attacks during alprenolol therapy. It is concluded that success in at least two-thirds can be expected with alprenolol. No serious complications or side-effects occurred during alprenolol treatment.
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Aubert et al. (1970) studied this question.
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