Why the study?
Does alprenolol in conjunction with pentanitrol improve total work performance compared to alprenolol alone in patients with angina pectoris?
Does alprenolol in conjunction with pentanitrol improve total work performance compared to alprenolol alone in patients with angina pectoris?
Alprenolol improves work performance in a subset of patients with angina pectoris, but the addition of pentanitrol provides no further benefit.
No added benefit from pentanitrol with alprenolol; leaves open efficacy in larger controlled angina trials.
Total work performance has been determined in 13 patients with angina pectoris during treatment with alprenolol alone and in conjunction with pentanitrol in a double‐blind study. Nine patients had a significant increase in work performance on alprenolol, but there was no difference between the two preparations. By measuring triple product and QS 2 index before and after a test dose of alprenolol, it may be possible beforehand to select responders to this treatment.
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Hansen et al. (1973) studied this question.
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