Population
Reovirus-infected mouse fibroblast L cells, vector-transfected cells, and rabbit reticulocyte lysates
Design
Preclinical
Authors
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No immediate clinical implications; leaves open AUG context effects on human protein synthesis.
The study provides direct evidence that initiation is a slow step of translation in vivo and that flanking nucleotide context affects ribosome pausing at AUG codons.
Doohan et al. (1993) studied this question.
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