Population
Cell-free extracts prepared from untreated and interferon (IFN)-treated mouse fibroblast L cells
Comparison
Reovirus messenger RNA purified by CF-11… vs LiCl-purified reovirus mRNA; extracts from…
Design
Preclinical
Authors
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Indicates mRNA-intrinsic features mediate IFN inhibition; leaves open in vivo relevance and extension to other mRNAs.
Highly purified reovirus mRNA is translated less efficiently in interferon-treated cell extracts, suggesting an integral property of the mRNA mediates this inhibition.
Jacobs et al. (1988) studied this question.
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