Why the study?
Does prehypertension and hypertension impair the in vivo endothelial repair capacity of early endothelial progenitor cells compared to healthy subjects?
Population
Early endothelial progenitor cells isolated from healthy subjects and newly diagnosed prehypertensive and…
Comparison
EPCs from prehypertensive and hypertensive… vs EPCs from healthy subjects
Design
Preclinical
Authors
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Impaired EPC repair in prehypertension may mark early vascular risk; leaves open whether targeting EPC senescence modifies hypertension outcomes.
Does prehypertension and hypertension impair the in vivo endothelial repair capacity of early endothelial progenitor cells compared to healthy subjects?
Prehypertension and hypertension are associated with impaired in vivo endothelial repair capacity and accelerated senescence of early endothelial progenitor cells, likely representing an early event in vascular disease development.
Giannotti et al. (2010) studied this question.
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