January 1, 2017Medical ArchivesOpen Access

Study of Echocardiographic Changes After Kidney Transplantation in End-stage Renal Disease Patients

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Why the study?

Does kidney transplantation improve echocardiographic findings in ESRD patients with baseline cardiac abnormalities?

Structured PICO

Does kidney transplantation improve echocardiographic findings in ESRD patients with baseline cardiac abnormalities?

Population

181 patients with end-stage renal disease (ESRD) and kidney transplant recipients with LVEF <50%, left ventricular hypertrophy, mitral valve regurgitation, and tricuspid valve regurgitation. Mean age 38.52, 54.7% men.

Intervention

Kidney transplantation

Comparator

Baseline (before kidney transplantation)

Outcome

Echocardiographic findings at 6 and 12 monthssurrogate

Kidney transplantation significantly improves echocardiographic parameters of cardiac function in ESRD patients over a 12-month period.

Implication

May improve CV status in ESRD; leaves open causal benefits pending prospective trials.

Abstract

BACKGROUND: Cardiovascular complications are the leading cause of mortality in end-stage renal disease (ESRD) patients. This study aimed to evaluate the efficacy of kidney transplantation on the cardiovascular status in ESRD patients. METHODS: During 2012 to 2014 and in a cross-sectional study, 181 patients were randomly selected for this study. All patients were followed for periods of 6 and 12 months after kidney transplantation. The patients with ESRD and kidney transplant recipients; the patients with left ventricle ejection fraction<50%, left ventricular hypertrophy, mitral valve regurgitation and tricuspid valve regurgitation were included to study and the patients with kidney transplant rejection, myocardial infarction, high blood pressure with treatment-resistant, high blood pressure and addicted patients were censored. RESULTS: one hundred and eighty-one patients had the mean age of 38.52 (range, 16-69 years) that 54.7% were men and the mean duration of dialysis was 3.74 years. There were significant differences after 6 and 12 months compared with before and also 6 months compared with 12 months from kidney transplantation for all echocardiographic findings. The echocardiographic findings improved after 12 months compared with 6 months and also these times compared with before kidney transplantation. CONCLUSIONS: The results of this study appeared that kidney transplantation had a positive effect on the cardiovascular status of patients with ESRD and improved the cardiac function of these patients.