Synergistic Dual Automaticity in Sinoatrial Node Cell and Tissue Models
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Why the study?
Does modulation of SR Ca2+ cycling and membrane currents affect sinus rate and pacemaker location in sinoatrial node cell and tissue models?
Population
Computer simulation of sinoatrial node cell and 1D tissue model consisting of 30 cells.
Comparison
Modulation of sarcoplasmic reticulum Ca2+… vs Baseline simulation conditions.
Design
Preclinical
Authors
Discussion
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Implication
SR Ca2+ modulation of sinus rate is hypothesis-generating in SAN models; leaves open any clinical relevance pending validation.
Structured PICO
Does modulation of SR Ca2+ cycling and membrane currents affect sinus rate and pacemaker location in sinoatrial node cell and tissue models?
P
Population
Computer simulation of sinoatrial node (SAN) cell and 1D tissue model (Maltsev-Lakatta SAN rabbit model) consisting of 30 cells.
I
Intervention
Modulation of sarcoplasmic reticulum (SR) Ca2+ cycling parameters (SERCA pump rate [Pup] and Ca2+ release rate [Ks]) and membrane ion currents (I_f, I_CaL, I_CaT).
C
Comparator
Baseline simulation conditions (e.g., Pup=12 mM/s, Ks=250 /μs).
O
Outcome
Sinus rate modulation, rhythmic firing stability, and leading pacemaker site location.surrogate
This computational modeling study demonstrates that sinoatrial node automaticity is synergistically regulated by both intracellular SR Ca2+ dynamics and membrane ion currents at both the single-cell and tissue levels.
Cite This Study
Zhang et al. (2010) studied this question.
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