Association of Cardiac Injury and Malignant Left Ventricular Hypertrophy With Risk of Heart Failure in African Americans
Why the study?
The factors underlying the transition from at-risk to clinical HF in African Americans, who bear a higher burden of HF, are not well understood.
Does the combination of left ventricular hypertrophy and subclinical myocardial injury increase the risk of incident heart failure in African Americans?
Population
3987 African American participants without prevalent HF in the Jackson Heart Study
Comparison
Categories based on presence or absence of LVH and subclinical myocardial injury (hs-cTnI)
Design
Prospective community-based cohort study
Follow-up
Median 9.8 years
Authors
Discussion
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Member takes
Implication
LVH and hs-cTnI may stratify HF risk among African Americans; hypothesis-generating and requires prospective validation before clinical use.
Structured PICO
Does the combination of left ventricular hypertrophy and subclinical myocardial injury increase the risk of incident heart failure in African Americans?
P
Population
3,987 African American adults without prevalent heart failure, 64% women, from Jackson, Mississippi.
I
Intervention
Presence of left ventricular hypertrophy (LVH) and subclinical myocardial injury (elevated hs-cTnI)
C
Comparator
Absence of LVH and subclinical myocardial injury
O
Outcome
Incident heart failure hospitalizationhard clinical
The combination of left ventricular hypertrophy and subclinical myocardial injury identifies a high-risk preclinical heart failure phenotype in African Americans, particularly men.
Cite This Study
Pandey et al. (2018) studied this question.