December 17, 1998Biochemistry

Expression and Purification of the Extracellular Ligand-Binding Domain of the Atrial Natriuretic Peptide (ANP) Receptor: Monovalent Binding with ANP Induces 2:2 Complexes

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Population

Extracellular ANP-binding domain of rat ANP receptor (NPR-ECD)

Design

Preclinical

Authors

KMKunio S. MisonoUniversity of Nevada, Reno NSNatarajan SivasubramanianHeart Failure & Transplant KBKathleen L. BerknerCleveland Clinic

Discussion

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Implication

Supports ANP-NPR activation model; hypothesis-generating for receptor-targeted therapies, with no clinical implications yet.

Structured PICO

Population

Extracellular ANP-binding domain of rat ANP receptor (NPR-ECD)

Intervention

Binding with atrial natriuretic peptide (ANP)

Outcome

Binding affinity, ligand selectivity, and complex formation (dimerization)surrogate

Binding of ANP to the extracellular domain of its receptor induces dimerization into a 2:2 complex, elucidating the initial step of receptor activation.

Cite This Study

Misono et al. (1998) studied this question.

synapsesocial.com/papers/6a73c625dcf9e352178de515 https://doi.org/10.1021/bi982127v

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Expression and Purification of the Extracellular Ligand-Binding Domain of the Atrial Natriuretic Peptide (ANP) Receptor: Monovalent Binding with ANP Induces 2:2 Complexes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Expression and Purification of the Extracellular Ligand-Binding Domain of the Atrial Natriuretic Peptide (ANP) Receptor: Monovalent Binding with ANP Induces 2:2 Complexes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider