Key result
Photoaffinity labeling identifies segment Asp191-Arg198 as the ANP covalent binding site on NPR-A.
Population
Bovine adrenal natriuretic peptide receptor type-A (NPR-A)
Design
Preclinical
Authors
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No immediate clinical impact on natriuretic peptide therapies; leaves open validation and therapeutic targeting of this domain in humans.
This basic science study identifies the specific segment Asp191-Arg198 on the natriuretic peptide receptor-A as the binding site for atrial natriuretic peptide.
McNicoll et al. (1996) studied this question. Photoaffinity labeling was evaluated on Identification of the ligand binding domain for atrial natriuretic peptide. Photoaffinity labeling identified the short segment Asp191-Arg198 as the site of covalent binding of atrial natriuretic peptide to the natriuretic peptide receptor-A.
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