Why the study?
The clinical significance of iron deficiency in heart failure patients with preserved ejection fraction is not well understood.
Iron deficiency in patients with HFpEF is associated with worse central hemodynamics and increased clinical manifestations of heart failure.
Iron deficiency screening may refine HFpEF risk stratification; leaves open whether repletion improves outcomes in randomized trials.
The clinical significance of iron deficiency in heart failure patients with preserved ejection fraction is not well understood. 158 patients with chronic heart failure with preserved ejection fraction were examined. The clinical manifestations of heart failure, the level of NT-proBNP, iron, ferritin, transferrin, were studied in all patients, echocardiography was performed in one-dimensional, two-dimensional, and Doppler modes (pulse-wave, constant-wave, and tissue) in standard positions according to the generally accepted technique. It has been established that iron deficiency in patients with heart failure with preserved ejection fraction worsens the indices of central hemodynamics and promotes an increase in the clinical manifestations of heart failure, especially in the development of anemia.
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Смирнова et al. (2020) studied this question.
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