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January 1, 1985BloodOpen Access

Von Willebrand factor in the vessel wall mediates platelet adherence

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Population

Human artery subendothelium exposed to normal flowing blood, blood from normal individuals, and blood from a…

Comparison

Monoclonal antibody CLB-RAg 35 directed against… vs Untreated normal vessel walls and blood without…

Design

Preclinical

Authors

HSHV StelUtrecht UniversityKSKS SakariassenRoche (Switzerland)PGPG de GrootAtrium Health Wake Forest Baptist

Discussion

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Implication

May inform shear-selective antithrombotic development; leaves open translation from animal models to clinical use.

Structured PICO

P
Population
Human artery subendothelium exposed to normal flowing blood, blood from normal individuals, and blood from a patient with severe homozygous von Willebrand's disease
I
Intervention
Monoclonal antibody CLB-RAg 35 directed against the von Willebrand factor moiety (vWF)
C
Comparator
Untreated normal vessel walls and blood without the antibody
O
Outcome
Platelet adherence to human artery subendothelium at varying shear ratessurrogate

This study demonstrates that von Willebrand factor present in the vessel wall is crucial for mediating platelet adherence at high shear rates.

Cite This Study

Stel et al. (1985) studied this question.

synapsesocial.com/papers/6a73d8e9dcf9e352178de730https://doi.org/10.1182/blood.v65.1.85.bloodjournal65185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood1995 · 53 citations
  2. 2Asialo-von Willebrand factor inhibits platelet adherence to human arterial subendothelium: discrepancy between ristocetin cofactor activity and primary hemostatic function1987 · 10 citations
  3. 3Distinct platelet interactions with soluble and immobilized von Willebrand factor modulate platelet adhesion and aggregation with differential impact on hemostasis and thrombosis2024
  4. 4Characterisation of a Monoclonal Antibody to von Willebrand Factor as a Potent Inhibitor of Ristocetin-Mediated Platelet Interaction and Platelet Adhesion1987 · 7 citations
  5. 5Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets1993 · 273 citations