Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 1, 1987Blood

Asialo-von Willebrand factor inhibits platelet adherence to human arterial subendothelium: discrepancy between ristocetin cofactor activity and primary hemostatic function

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does asialo-von Willebrand factor inhibit platelet adherence to human arterial subendothelium in vitro?

Population

Normal citrated whole blood perfused over human umbilical artery segments (in vitro model)

Comparison

Asialo-von Willebrand factor 4 micrograms/mL or… vs Citrated whole blood or intact vWF 4 micrograms/mL

Design

Preclinical

Authors

JLJeanne B. LawrenceUniversity of Massachusetts Chan Medical SchoolHGHR GralnickNational Institutes of Health

Discussion

Loading...

Member takes

Implication

AS-vWF inhibits platelet adhesion in vitro; hypothesis-generating for vWF glycosylation effects on primary hemostasis, requiring in vivo studies.

Structured PICO

Does asialo-von Willebrand factor inhibit platelet adherence to human arterial subendothelium in vitro?

P
Population
Normal citrated whole blood perfused over human umbilical artery segments (in vitro model)
I
Intervention
Asialo-von Willebrand factor (AS-vWF) 4 micrograms/mL or asialo, agalacto-vWF (AS,AG-vWF) 4 micrograms/mL
C
Comparator
Citrated whole blood (control) or intact vWF 4 micrograms/mL
O
Outcome
Total platelet adherencesurrogate

Asialo-vWF is a potent inhibitor of platelet adherence to subendothelium despite enhanced ristocetin cofactor activity, suggesting vWF carbohydrate abnormalities may impair primary hemostasis.

Cite This Study

Lawrence et al. (1987) studied this question.

synapsesocial.com/papers/6a85597a35bc0eada8d597adhttps://doi.org/10.1182/blood.v70.4.1084.1084
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spectrum of von Willebrand's Disease: a Study of 100 Cases1977 · 105 citations
  2. 2The Thiobarbituric Acid Assay of Sialic Acids1959 · 6,444 citations
  3. 3Mapping of distinct von Willebrand factor domains interacting with platelet GPIb and GPIIb/IIIa and with collagen using monoclonal antibodies1986 · 91 citations
  4. 4Properties of human asialo-factor VIII. A ristocetin-independent platelet-aggregating agent.1981 · 127 citations
  5. 5Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor.1985 · 65 citations