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January 1, 1990Thrombosis and Haemostasis

Platelet Adhesion to Collagen in Subtypes of Type I von Willebrand’s Disease Is Dependent on Platelet von Willebrand Factor

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Why the study?

Does platelet von Willebrand factor contribute to platelet adhesion in subtypes of Type I von Willebrand's disease?

Population

Patients with subtypes of Type I von Willebrand's disease, severe von Willebrand's disease, and normal…

Comparison

Perfusion studies using a rectangular perfusion… vs Normal controls and severe von Willebrand's…

Design

Preclinical

Authors

PDPatrizia d’AlessioGenopole (France)JZJaap Jan ZwagingaSanquinHBHetty C. de BoerLeiden University Medical Center

Discussion

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Implication

Platelet vWF may support adhesion in Type I vWD on collagen; leaves open human relevance and clinical translation.

Structured PICO

Does platelet von Willebrand factor contribute to platelet adhesion in subtypes of Type I von Willebrand's disease?

P
Population
Patients with subtypes of Type I von Willebrand's disease (platelet normal, platelet discordant, and platelet low), severe von Willebrand's disease, and normal controls
I
Intervention
Perfusion studies using a rectangular perfusion chamber with fibrillar collagen or a fibroblast matrix as adhesive surfaces
C
Comparator
Normal controls and severe von Willebrand's disease
O
Outcome
Platelet adhesion to fibrillar collagen or fibroblast matrixsurrogate

Platelet von Willebrand factor contributes to platelet adhesion on strongly activating surfaces like fibrillar collagen when plasma von Willebrand factor levels are low in Type I von Willebrand's disease.

Cite This Study

d’Alessio et al. (1990) studied this question.

synapsesocial.com/papers/6a9889a74bb95f5cc076b0d5https://doi.org/10.1055/s-0038-1647290
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of platelet von Willebrand factor in platelet adhesion and thrombus formation: a study of 34 patients with various subtypes of type I von Willebrand disease1994 · 40 citations
  2. 2Deficiency of platelet membrane glycoprotein Ia associated with a decreased platelet adhesion to subendothelium: a defect in platelet spreading1986 · 14 citations
  3. 3Platelet adhesion to collagen in healthy volunteers is influenced by variation of both α2β1 density and von Willebrand factor2000 · 4 citations
  4. 4On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood1995 · 53 citations
  5. 5Differentiation of patients with subtype IIb‐like von Willebrand's disease by means of perfusion experiments with reconstituted blood1985 · 15 citations