What question did this study set out to answer?

To determine the binding characteristics and receptor affinity of factor VIII/von Willebrand factor protein to platelets in type IIB von Willebrand's disease.

August 1, 1982BloodOpen Access

Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets

View Full Paper

Ask AI

Bookmark

Population

Two families with type IIb von Willebrand's disease and macrothrombocytopenia

Design

Other

Authors

HGHR GralnickRutgers, The State University of New Jersey WSWilliams SbNational Institutes of Health Clinical Center BSBC Shafer

Discussion

Member takes

Implication

Suggests altered platelet receptor topography in type IIb vWD; hypothesis-generating and should not yet change practice.

Key Points

To determine the binding characteristics and receptor affinity of factor VIII/von Willebrand factor protein to platelets in type IIB von Willebrand's disease.
Evaluated platelet binding in individuals from two families affected by type IIB von Willebrand's disease and macrothrombocytopenia.
Analyzed the binding capacity and affinity for normal and intermediate-sized factor VIII/von Willebrand factor multimers compared with normal platelets and control platelets from other etiologies.
Type IIB platelets bound greater amounts of normal and intermediate-sized factor VIII/von Willebrand factor multimers than normal platelets.
Binding analysis demonstrated increased receptor affinity for factor VIII/von Willebrand factor on type IIB platelets compared to normal platelets, other disease subtypes, and large platelets of other etiologies.

Structured PICO

Population

Two families with type IIb von Willebrand's disease and macrothrombocytopenia

Comparator

Normal platelets, platelets of other vWd patients, and large platelets of other etiologies

Outcome

Binding affinity and quantity of factor VIII/von Willebrand factor to plateletssurrogate

Type IIb von Willebrand's disease platelets exhibit increased affinity for factor VIII/von Willebrand factor, suggesting an increased number or altered topography of platelet receptors.

Cite This Study

Gralnick et al. (1982) studied this question.

synapsesocial.com/papers/6a8558f388f8834812671add https://doi.org/10.1182/blood.v60.2.328.328

View Full Paper

Ask AI

Bookmark

Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Factor VIII/von Willebrand factor binding to von Willebrand's disease platelets

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider